When I lived in Tampa Florida we made one or two trips a year to the Panhandle of Florida. We fished Mexico Beach close to Panama city. Great fishing with Charisma charters.
http://www.charismacharters.com/We also rented a beach house in Cape St. Blas. Great flats fishing and great fun with the grandkids snorkeling for bay scallops in the clear bay waters (knee deep where you get the scallops). I caught my biggest trout ever in front of our rental house in the surf.
http://www.visitgulf.com/We also rented a shore house on St George island and had unbelievable fishing for pompeno and big flounder at the land cut at the south end of the island.
http://www.resortvacationproperties.com/All of these places were near enough that we went deepsea fishing with charisma charters for one day on each vacation.