I'd make the drive to Indianola, unless you want nice accommodations. Not much there, but fishing Powderhorn is like fishing a giant stock tank with reds in it. Stick to the shoreline and fish under the overhanging trees. You can park next to the LaSalle statue, hop the parking rail and launch your 'yak. I've caught some really nice reds right there, within 30 feet of the truck, just casting under the willows. When you're through you can go up to the store for a cold beer and a good burger, even toss out a surf rod into the cut, if you want, that's about $5 for a fishing pass, though.