If you are looking specifically for bigger fish then the trees and duck blinds on the main part of the lake would be the best option. This can be very slow until you run across the right group of trees.
If you get bored with that head up into Big Cypress. To me, the fish are easier to catch up there because they are easier to pattern. I've never caught anything over 5 up there, but it is alot of fun once you figure out what they are doing.
I haven't fished it this year yet so the current is the unknown factor. If it is too high you would probably do better in one of the creeks feeding the bayou.