I lived and fished in Destin for a number of years while stationed nearby. April/May are prime fishing months with the pompano run starting mid/late April. Here's my advice for simple, effective vacation fishing.
Bring a 7' medium rod with 10-20lb test, pick up some pompano jigs from Half Hitch, local tackle shop. Walk out to jetties/pier/surf and tip the jigs with fresh shrimp tail or live sand fleas. Cast out, let sink, jig, jig, jig, set the hook! You'll get into pompano, reds, Spanish, whiting, ladyfish, bluefish, and maybe even a trout/flounder or two. It's all I do when I go back and vacation there. Not a lot of gear needed. Pocket full of jigs and bucket of shrimp/fleas. Enjoy!