We are heading to Pensacola Beach the first week of May and booked a fly fishing day trip with Captain Eddie, at http://fullnetfishingcharters.com/
I start lurking around http://www.pensacolafishingforum.com/
for local information. We plan on doing a little fishing on our own too.
I realize this isn't Destin, but you might get some ideas and could possibly post on the Pensacola forum for more information.
Just a thought.